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Cancer Immunology: 

 

  1. Understanding the role of immune cells in tumour progression : It is now well established that immune system has a pivotal role in cancer progression. Different immune cells, receptors, checkpoint inhibitors along with other stromal cells control the proliferation of clone of cancers cells.  Presently our group is working to understand the cross talk between immune cells: Monocyte /Macrophage and breast cancer cells. Group  also looking for soluble markers for breast cancer.
     

  2. Discovery of the Surface Localization of Toll -like Receptor 3 in Cancer Cell:  It has been known for long time that Innate immune receptor -TLR3, locating inside the endosomal compartment of the cells, promote apoptosis. Accordingly, ligands of TLR3 had been used as adjuvant therapy in several clinical trials. Group first time discovered that TLR3 also present on cell surface apart from endosomal compartment and induce cellular proliferation instead of apoptosis.
     

  3. Discovery of cell surface mediated MyD88 -TLR3 signalling cascade: It has been known earlier that TLR3 use TRIF mediated signalling pathway to induce apoptosis. Very recently group has discovered that when TLR3 is present on the surface of the cancer cell cells, uses different signaling pathway involving MyD88 - NFkB mediated signalling cascade to influence cellular proliferation. 
     

  4. Clinical relevance of TLR2, TRR4  and TLR 9 in cervical and breast cancer:  Group is pio  showed  the diagnostic and prognostic importance of TLR2 and TLR9  in breast and cervical cancer. It has already been  showed the role of different proteases in epithelial to mesenchymal transition (EMT) for breast cancer metastasis. Accordingly, our group has reported  that TLR 4 expresses in non-immune ductal epithelial cells of the breast cancer and can be responsible  for the  cellular invasiveness (Published several papers in reputed journals) 

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